Join us

At Korro Bio, we look at things differently. We take historically complex methodologies and strip them down to their most basic science to deliver sophisticated therapies for patients with debilitating disease.

Our
mission

Our OPERA (Oligonucleotide Promoted Editing of RNA) technology aims to restore health for patients with one single-letter edit.

We are a growing, dedicated group of researchers and industry veterans with a vision to deliver the next generation of RNA editing therapeutics. We are currently building our team in Cambridge, MA, and are always looking for individuals who are passionate about developing innovative therapies for patients to join our growing team. Sound like you?

If you share our vision, check out our open positions below and send us an email: careers@korrobio.com.

Join the Korro Bio crew.
Come help us rewrite the future for patients.

  • Associate Director/Director, Project Management

    Location: Remote (during COVID)

    Company Summary:   Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

    We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

    Position Summary: We are seeking a dynamic Project Manager, to support our research efforts. The role requires a strategic leader who is experienced in drug development and understands the essential process, its complexity and its interdependencies.  A primary element, in the successful execution of this role will be establishing strong relationships across the program management roles that exists within line functions (Clinical Development, Pre-clinical Research etc.).  Through the leadership and facilitation of cross-functional program teams, this role is accountable for establishing a development plan, and an integrated cross-functional development strategy that includes timelines (including Gantt charts); dashboards and tools that provide transparency; budget inputs; identifying/highlighting risks and creating mitigation and/or contingency plans; and the attainment of key business goals/milestones.  This position will report to the Chief Legal Officer & Head of Corporate Strategy, and be based in our Cambridge, MA office.

    Key Responsibilities:  

    • Work proactively with the cross-functional program teams to define program strategy, goals, decision points, investments and areas of risk and associated mitigations and contingencies.
    • Develop and maintain a fully integrated project plans (Gantt), incorporating activities, resource requirements, assumptions, responsibilities, and key interdependencies, key resource requirements and critical analysis that facilitate the delivery of quantifiable results against program and corporate goals.
    • Lead data-driven decision-making processes to enable timely and objective recommendations for continuation, acceleration, reprioritization, redesign of the development plan.
    • Communicate progress at all levels and escalate critical issues; provide regular status reports
    • Identify, define, prioritize and communicate risks to successful activity and execution; develop and monitor risk mitigation and contingency plans.
    • Track against R&D team budgets and contribute to long-range plan forecasts.
    • Support the Leadership Team in setting goals and priorities developing agendas and planning workshops.
    • Provide team and meeting management, including taking minutes and ensure follow-up of action items from the minutes. Prepare presentations as needed.
    • Partner with R&D team to ensure effective coordination of activities and/or deliverables across functions, including assisting with the coordination and monitoring of external projects.
    • Support implementation of systems and best practices to ensure consistency and operational effectiveness within and across functions and programs.
    • Reinforcing or supporting team operating principles, team building, ensuring effective and high performing team.
    • Supporting management of internal governance and decision-making processes.

    Required Qualifications:

    • B.S./M.S. degree in a life sciences discipline; advanced degree and/or MBA strongly preferred.
    • A minimum of 7-10 years drug development experience in the biopharmaceutical industry including a minimum of 5 years project management or equivalent experience.
    • Strong understanding of the drug development process in cell and/or gene therapy, including the strategic and operational requirements.
    • Proven track record of success in leading and managing cross-functional development teams. Prior experience managing project to NDA submission a plus.
    • Competency in developing, implementing, and delivering project plans (Gantt), dashboards and risk mitigation and contingency plans to successful endpoints.
    • Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and, in a cross-functional team environment.
    • Demonstrated success with handling multiple projects and able to handle complexity and prioritize effectively.
    • Proven success working in cross-functional teams with strong scientific and knowledge.
    • Track record of collaboration, stakeholder relationship management, and influencing key decision makers.
    • Knowledge of and skill with project management, spreadsheet and database management software/tools.
    • Strong verbal and written communication skills.
    • Ability to leverage broader perspectives and connect the major elements of drug discovery and development to proactively identify opportunities and provide options/solutions.
    • Strong interpersonal skills, self-awareness, and ability to manage team dynamics.
    • Must be motivated, creative, energetic and adaptable, responding constructively to challenging new ideas, information and situations.
    • Demonstrated ability to operate successfully in a fast-paced, dynamic and complex environment.

    Benefits:

    Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

  • Laboratory Manager

    Location:  On-site, Cambridge

    Company Summary:   Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

    We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

    Position Summary: Korro Bio is seeking an experienced Lab Manager with excellent communication, interpersonal and managerial skills to manage and maintain our labs and operations.
    The Lab Manager will play a vital role in the overall organization, operation, and safety of the lab and will collaborate with R&D members to provide general support of their experiments. The successful candidate will have demonstrated a successful track record in laboratory and team management. The candidate will be well versed in permitting, training and reporting requirements as set forth by local, state, and federal regulations. Most importantly, the right candidate will be confident, passionate, execution-focused, team-oriented and has a can-do attitude and the ability to work collaboratively with others.

     

    Key Responsibilities:  

    • Oversee facility operations, including: equipment sourcing, procurement, maintenance, managing/tracking of biohazardous and chemical waste; and management of overall lab organization and cleanliness.
    • Serve as the primary point of contact with vendors and laboratory service providers; serve as primary emergency response contact.
    • Coordination and ensure scheduling of routine maintenance of various machines
    • Oversee safety consultant and conduct orientation and annual safety training for all lab personnel
    • Assist with space and work-flow planning, including planning and project management of moves and buildouts.
    • Implement and maintain lab inventory system and handle ordering of common supplies, including consumables, liquid nitrogen/cell storage, chemical reagents.

     Required Qualifications:

    • Education: BS/MS with 5+ years in biology, chemistry, or a related field.
    • Prior hands-on laboratory operations experience in a production laboratory is required.
    • Excellent organization skills, ability to multi-task and desire to be part of a growing team.
    • A desire to learn new things, the ability to remain flexible in a dynamic work environment and adjust priorities in a timely manner.
    • Excellent written, verbal communication and problem-solving skills
    • Experience as biosafety and/or chemical safety officer

    BenefitsKorro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

     

     

  • Head, Data Science

    Job Title:
    Head, Data Science

    Location:
    Remote (during COVID)

    Company Summary:
    Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

    We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

    Position Summary:
    Korro Bio is seeking a driven, smart and creative scientific leader whom will be responsible for building and leading Korro’s Data Science team. In addition to providing strategic and team leadership, key contributions for this position include the establishment and oversight of bioinformatic discovery using complex genomic data, including high throughput sequencing data from multiple platforms and databases.  Such work includes both internal and CRO based resources.  This scientific leader will have deep expertise in computational biology and in discovery research.  Core competencies include an ability to function in an interdisciplinary and quickly paced startup environment coupled with a proactive and collaborative approach. This position will report to the SVP of Technology.

    Key Responsibilities:  

    • Function as a key member of Korro Bio’s scientific leadership team, providing scientific expertise, strategic planning, and goal-oriented execution.
    • Build, lead and mentor a small team of Bioinformatics & Data Scientists.
    • Partner with other groups (e.g. informatics, platform biology, pharmacology) within research and development to facilitate lead identification, optimization and development candidate nomination.
    • Identify appropriate CROs and manage contract research to ensure success in meeting Korro’s chemistry goals and milestones.
    • Build strong relationships enabling trust, respect and effective collaboration cross disciplinary colleagues to ensure productive and successful company-wide research and development programs.
    • Serve as a role model and foster a scientifically rigorous, open and supportive corporate environment
    • Effectively communicate scientific planning, progress and results to Korro’s executive leadership, R&D teams, and external audiences. Additionally, build and develop appropriate relationships with key opinion leaders and SAB members.

    Required Qualifications:

    • Ph.D. in quantitative discipline or comparable experience: Bioinformatics, Statistics, Applied Mathematics, Computer Science, Biophysics, Computational Biology, Physics, Engineering or Machine Learning. M.S. degree with extensive (at least 10 years) Industry experience will also be considered.
    • Minimum of 10 years of Industry experience with proven leadership and management skills, ability to build and mentor high- performing teams.
    • Experience analyzing gene therapy, gene editing, in vitro/vivo assay, genetics, genomics and cell biology data
    • Experience analyzing the multiple facets of next generation sequencing data, including amplicon sequencing, tag counting, exon sequencing
    • Experience using comparative genomics as a tool for gene discovery
    • Passionate scientist and leader with high emotional intelligence and communication skills adept at working in a rapidly growing and dynamic biotech environment whom is able to progress programs under aggressive timelines.
    • Pragmatic, solution-oriented thinker who possesses a “can do” and “whatever it takes” attitude, coupled with excellent organizational skills.
    • Hands-on approach with meticulous attention to detail.
    • Strong interpersonal skills with the ability to motivate and influence others, negotiate during situational conflict and establish the best forward path in the face of competing points of view.
    • Track record of collaboration, stakeholder relationship management, and influencing key decision makers.

    Benefits
    Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

  • Director, of Oligo Delivery

    Company
    Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

    We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

    Position Summary
    Korro Bio is seeking an accomplished scientific leader who will play a key role in oligonucleotide delivery. The successful candidate will help identify delivery opportunities and optimize solutions across tissues and cell types. In this role, you will work closely with our internal groups such as: chemistry, screening, target biology, data science and development, as well as establish and maintain relationships with external collaborators and CROs.  The successful candidate will have a strong background in nucleic acid delivery, pharmacology, cellular trafficking as well as biochemical and cellular analysis.

    Full-time, Onsite Only

    Key Responsibilities

    • Function as a key member of the research organization and be the person who knows everything about oligonucleotide delivery.
    • Use your knowledge of oligo delivery to help guide a deeper understanding of and identify delivery solutions.
    • Partner with other groups within research and development to help facilitate lead identification, optimization and development candidate nomination.
    • Identify advisors and collaborators to help drive innovation in oligo delivery.
    • Identify and execute on opportunities to improve and advance delivery.
    • Serve as a role model and foster a scientifically rigorous, open and supportive scientific environment.
    • Effectively communicate scientific planning, progress and results to constituencies within and outside of Korro.
    • Communicate status updates and program issues to appropriate team members.

     

     

     

    Required Qualifications

    • Ph.D. in a relevant biological or chemical science.
    • 10+ years of experience in solving complex problems in discovery or drug development, preferably in a biotech environment.

    Other Knowledge, Experience or Skills Recommended

    • Demonstrated accomplishment in the field of nucleic acids through publications and presentations and/or a track record in industry.
    • Ideally have experience in all methods of oligonucleotide delivery including LNPs, oligo conjugates and other modes of delivery.
    • Strong knowledge and hands-on experience with oligonucleotide delivery strategies.
    • Experience with oligonucleotide pharmacology.
    • Must be able to coordinate activities and integrate information across different functional groups including cell biology, pharmacology and chemistry.
    • Demonstrates a proactive and collaborative philosophy and a hands-on approach to getting things done.
    • Excellent written and communication skills to a variety of levels/teams- internally and externally.
    • Must be able to identify and cultivate relationships with advisors and collaborators.
    • Experienced in the delivery of oligo-based therapeutics to liver and other tissues with a proven track record of successfully solving drug delivery challenges would be ideal.
    • Enthusiasm for being a hands-on manager with a passion for getting things done, no matter what it takes.

    Benefits
    Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

     

  • Scientist/Senior Scientist, ADAR Chemistry and Assay Development

    Company
    Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

    We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

    Position Summary
    Korro Bio is seeking a creative and rigorous scientist who will play a key role in continuing to drive our understanding of RNA editing through biochemistry and assay development. The successful candidate will work on characterization of ADAR/RNA and other biochemical processes and interactions and will develop, scale and implement new assays. This position will work closely with colleagues in chemistry, screening and target biology and other groups to expand our understanding of ADAR biology and biochemistry.

    Position Type
    Full-time, Onsite Only

    Responsibilities

    • Use your knowledge of biochemistry and protein nucleic acid interactions to help drive our RNA editing pipeline and platform
    • Partner with other groups within research and development to help develop and implement assays to facilitate lead identification, optimization and development candidate nomination
    • Identify collaborators to help drive innovation in RNA editing
    • Effectively communicate scientific planning, progress and results to constituencies within and outside of Korro
    • Execute deliverables adhering to timelines and budgets in a fast-paced environment
    Qualifications
    • Ph.D. in a biochemistry or related field with post-doc and/or industry experience
    • Must have experience working with RNA-binding proteins
    • ADAR specific experience is preferred
    Other Knowledge, Experience, and Skills
    • Expertise in biochemical characterizing of protein/RNA interactions
    • Ability to implement and scale protein/nucleic acid binding assays and measure binding and enzyme kinetics
    • Previous work with protein and enzyme expression and purification
    • Experience performing SAR is preferred
    • Must have excellent oral and written communication skills
    • Ability to collaborate cross functionally with all relevant areas to support strategic objectives
    • Pragmatic, solution-oriented thinker who possesses a “can do” and “whatever it takes” attitude, coupled with excellent organizational skills
    • Hands-on approach with meticulous attention to detail
    • Ability to effectively communicate and present data to a variety of levels/teams- internally and externally
    • Must be able to work on multiple projects simultaneously in a rapidly changing environment

    Benefits
    Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.