Join us

Company Summary:   Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary: We are seeking a passionate and creative Bioinformatics Associate to join our Data Science team and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company. This position reports to the Vice President, Data Science.  The successful candidate will have a strong background in Computer Science, Data Management and Data Engineering.

Key Responsibilities:  

• Design and implement data workflows to automate the data extraction, transformation and loading from the high-throughput screening experiments.
• Create the dashboards to summarize and visualize the results of high throughput screening experiments.
• Manage data in the compound database and laboratory information systems.
• Develop, operate and maintain data process pipelines and cloud applications.
• Partner with IT and other functions to deploy the data management systems and applications.
• Document the data management procedures and provide informatics application training for lab scientists.

Required Education, Skills and Qualifications:

• Master’s Degree in Computer Science, cheminformatics, bioinformatics or a related field with 1-2 years’ experience or BS degree with 2-3 years’ experience.
• Proficiency in Python and R.
• Familiar with data flow and data management in high throughput experiments.
• Knowledge of cloud computing and statistical analysis is a plus.
• Excellent attention to detail and documentation.
• Motivated team player.
• Strong interpersonal and communication skills (Oral/Written).
• Ability to balance multiple high-priority tasks in a rapidly changing environment

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Company Summary:   Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary: Korro Bio is looking for a Sr. Scientist in the Translational Pharmacology group. The successful candidate will contribute to drug discovery efforts in the following areas, liver, ophthalmology, and neurological diseases. The qualified candidate is a highly motivated, interactive, and creative bench scientist who will conduct experiments utilizing genetically engineered mouse models to advance discovery programs to IND. The successful candidate will demonstrate clear and professional communication, effectively collaborate with colleagues across a highly matrixed environment, and be capable of presenting scientific results to project teams.

Key Responsibilities:  

• Design, conduct and advise on pharmacology studies related to complex in vivo models focused on liver, ophthalmology, and neurological diseases.
• Conduct experiments and develop assays critical to understand in-vivo therapeutic activity, efficacy, and PK/PD properties.
• Executing ex vivo assays to investigate target engagement, mechanism of action and biomarkers by the following techniques: DNA/RNA extraction, qPCR, ELISA (MSD), and WB.
• Coordinate and manage studies remotely at CROs and external collaborators.
• Breeding and colony maintenance of transgenic mouse strains.
• Documentation of assay development and in vivo study results.
• Mentor/manage junior associates and colleagues on best practices in the laboratory.

 

Required Skills and Qualifications:

• Ph.D. in Pharmacology with 5-7 years of experience in industry setting or MS with 10+ years in industry setting.
• Prior experience designing and executing in vivo studies with murine and rat models a must.
• Ability to use animal models and a variety of high throughput tools including expression analysis, transcriptional profiling, AAV, in situ hybridization and immunohistochemistry.
• Experience in Oligonucleotide based therapeutics or gene editing is a plus.
• Attention to detail with excellent organizational and record keeping skills.
• Ability to work collaboratively across departments, understand and implement applicable regulations around animal care/safety/handling desired.
• Highly motivated and ability to be flexible in case of changing priorities.
• Strong written and verbal communication skills with the ability to interact effectively with peers and management. Capable of presenting scientific results to multidisciplinary teams and key stakeholders.
• Proficiency in utilizing software such as GraphPad Prism, electronic lab notebooks, Microsoft Office etc. for data analysis and figure generation is required.

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

Company Summary:   Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target sequences within the genetic code that are responsible for inherited disorders. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and career development at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary: We are seeking a driven, smart and creative chemist who will be responsible for helping to lead Korro’s chemistry team. In addition to providing strategic guidance and team leadership, key contributions for this position include overseeing synthesis of research oligonucleotides and oligonucleotide conjugates both internally and at external vendors. This scientific leader will have deep expertise in nucleic acid medicinal chemistry (siRNA, RNAi, antisense, exon skipping) to enable platform and therapeutic program development.  Further the candidate will function as a resource for development efforts including scale up of molecules.  Core competencies include an ability to function in an interdisciplinary and fast-paced startup environment coupled with a proactive and collaborative approach. This position reports to the Head of Chemistry and will be based in our Cambridge, MA location.

Key Responsibilities:  

• Provide chemistry leadership to advance cutting edge research of oligonucleotide therapeutics
• Develop and execute discovery project plans that will address multiple target and indication opportunities in line with strategic direction determined by the leadership team
• Operational oversight of internal and external medicinal, synthetic and analytical chemistry workstreams supporting Korro’s discovery and development portfolio
• Help to build and manage a network of CROs and CMOs to augment internal capacity
• Responsible for management of timelines, resourcing and budget planning
• Partner with other groups (e.g., informatics, platform biology, pharmacology) within the organization to facilitate lead identification, optimization, and development candidate nomination

• Build strong cross-disciplinary relationships to enable productive and successful company-wide research and development programs
• Serve as a role model and foster a scientifically rigorous, open and supportive corporate environment
• Help to build a world-class oligonucleotide chemistry organization by recruiting top talent from across the industry
• Effectively communicate scientific planning, progress and results to Korro’s executive leadership, R&D teams, and external audiences

Required Qualifications and Skills:

• Ph.D. in chemistry with at least 7 years of experience in drug discovery and development of oligonucleotide therapeutics
• Demonstrated success in the design, chemical optimization, and formulation/delivery of oligonucleotide therapeutics
• Experience operating oligonucleotide synthesizers such as AKTA Oligopilot, Dr Oligo and MerMade and associated downstream processing equipment for purification (IEX, RP), desalting and lyophilization
• Expert knowledge of oligonucleotide delivery modalities and wet-lab experience with oligonucleotide conjugation chemistries
• Ability to lead from the bench when required
• Prior management experience is strongly preferred
• Prior experience in chemistry supporting successful IND and/or NDA submissions is preferred
• Outstanding scientific leadership and collaboration skills Excellent verbal and written communication skills
• Outstanding interpersonal skills, self-awareness, and ability to manage team dynamics

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

Executive Assistant

 Position Summary:  Korro Bio is looking for an experienced Executive Assistant to join our expanding team at Korro Bio.  This individual will be responsible for providing critical administrative support and assistance for our assigned executive R&D Team and Senior Leaders.  This role requires impeccable organizational, communication, administrative, and collaborative skills.  The candidate should have solid administrative experience, a high level of professionalism and be able to work effectively in a fast paced, rapidly growing and changing environment where initiative, self-confidence, flexibility, adaptability, and discretion are critical to being successful in this role.

Key Responsibilities:

Responsibilities including but not limited to:

• Demonstrates high level of discretion, confidentiality, and good judgment in execution of all responsibilities.
• Organizes and manages complex calendars for executive team members, resolving any scheduling issues.
• Coordinates internal/external meetings with efficiency and detail; communicating clearly to explain conflicts and need to re-prioritize.
• Manages standing meetings and off sites with leaders’ teams as required.
• Provide site support as needed (events, coordination of meetings, administrative tasks, etc.).
• Oversees all aspects of conference attendance for team – registration, travel, pre-attendance prep meetings.
• Draft and prepare Word, Excel, PowerPoint presentations, decks, agendas, reports, special projects, and other documents in support of objectives for the executive team and the organization.
• Handles executive travel arrangements (domestic/international) and creates trip itineraries.
• Prepares expense reports in a timely fashion and provides budget support between team and finance.
• Effectively and proactively analyzes needs and problems and determine approach and priority in collaboration with senior leaders, their teams, and colleagues across functions.
• Participates in maintenance and improvement of processes; implement changes to improve processes for direct responsibilities.
• Ability to function well in a high-paced environment; performs additional duties as assigned by executive team members.

 

 

• Supports team communications between group and across functions.
• Works closely with Head of Administration to provide ad hoc support, as needed.
• Performs other administrative duties; office and front desk support as required.

Required Education, Skills, And Experience

• Bachelor’s degree required or commensurate experience.
• 5+ years of related experience required in working in an executive assistant role supporting C-Level executives.
• Advanced Proficiency in Microsoft Office (Outlook, Word, Excel, and PowerPoint).
• Ability to communicate effectively and professionally.
• Has a strong business sense and can decipher priorities and make sound judgment calls when needed.
• Commitment to excellence – perform duties at the highest level possible on a consistent basis.
• Demonstrates ability and temperament to work with sensitive information.
• Team player – has team-oriented experience and approach.
• Ability to work independently and to think outside of the box with a good sense of priority and urgency.
• Has a positive attitude and good sense of humor.

Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

Job Title:  Vice President, Business Development

Location:  One Kendall Square

Company Summary:  Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary: Korro Bio is seeking a passionate and resourceful Vice President of Business Development.  The successful candidate will drive the entire BD process from search/evaluation to deal execution. This individual will lead business development efforts in the identification, evaluation and development of acquisition, in-licensing, out-licensing and partnership opportunities inclusive of assessing external opportunities relative to our internal pipeline choices and investments. The Vice President of Business Development possesses strong scientific expertise in the biopharmaceutical industry and business development leadership, in various therapeutic areas.  The ideal candidate will have the ability to think holistically and long-term across a broad spectrum of industry trends and issues in base editing, gene editing, RNA therapeutics, rare disease, and platform approaches, and to communicate long term business objectives and priorities through external partnerships. A deep understanding of the drug discovery, development, and regulatory processes is required, as this position will lead both scouting activities and evaluation/diligence of novel therapeutic opportunities for both licensing and M&A, while supporting transactional activities. This position reports to the Chief Operating Officer.

Key Responsibilities:  

• Independently lead search and evaluation activities and projects in the base editing, gene editing, RNA therapeutics, and oligo delivery field to proactively identify and solicit new strategic research partnerships with biotech and pharmaceutical companies, academic institutions, non-profit research or patient organizations.
• Participate in and lead in-depth reviews and due diligence on external opportunities.
• In collaboration with R&D organization and SVP of Strategy and Portfolio Planning, lead the activities/input necessary to establish the business case (scientific/ technical evaluation, development plan, market research, market opportunity, competitive intelligence, strategic assessment, appropriate transaction financial structure etc.) and present it to senior leaders in the business.
• Own the overall execution of an evaluation project providing oversight to the BD team membership involved in the project as well as cross-functional membership.
• Identify, analyze, and act on opportunities for growth through cultivating relationships, negotiating, and reviewing contracts.
• Provide insights and commercial advice while maintaining an understanding of the industry trends, best practices, and industry financial measurements.
• Responsible for building business cases; assessing commercial plans, market opportunities, and transaction financial structure for prospective partners.
• Act as the company’s BD Leader while collaborating with other team members to achieve objectives.

 

 

Required Qualifications:

• MD, PhD, PharmD, or other advanced degree in the biomedical field required.
• Minimum 15 years of experience within the biopharmaceutical industry or related biotech/healthcare practice and minimum 5 years of experience in S&E in a business development organization
• Experience in sourcing and evaluating pharmaceutical or biotech products, for potential licensing /acquisition.

  Other Knowledge, Experience or Skills recommended:

• Must have an aptitude to quickly understand new science and technology.
• Display strong interpersonal skills and work with multiple internal stakeholders to drive and support highly visible and time-sensitive business development projects.
• Ability to establish and maintain relationships with academic institutions, vendors, biotechnology and pharmaceutical companies, and the VC community.
• Ability to co-lead with transactions to develop and deliver scientific, clinical, technical, and commercial assessments and evaluations in base editing, gene editing, RNA therapeutics and oligo delivery field to the relevant internal governance bodies.
• An outstanding strategist and thought partner to the leadership team.
• Leadership ability that inspires and drives internal teams.
• Strong collaboration and influence skills. An ability to work across all lines as a general advisor and across the leadership team as a trusted partner, yet capable and willing to challenge established thinking to realize a better outcome.
• Increase awareness of Korro Bio’s strategy to the external environment.
• Business development experience within pre-clinical and/or clinical stage business development.
• Requires demonstrated knowledge and understanding of pharmaceutical development and commercialization and business practices required to successfully bring drugs to market.
• Self-starter who is able to effectively lead multiple projects simultaneously.
• Experience working with all levels of management and consulting with key business stakeholders.
• Strong ability to influence for greater outcomes.
• Strong team player that has a customer service approach and is solution oriented.
• Attention to detail and the ability to work individually, within a multi-disciplinary team, as well as with external partners and vendors.
• Possesses strong written and verbal communication skills.

Benefits: Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Company Summary:  Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary: Korro Bio is seeking a passionate and creative team leader with expertise in liver biology to join our Research group and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company.  Reporting to the Head of Liver Biology, the successful candidate will lead focused efforts on the validation of novel targets and the evaluation of novel drug candidates for the treatment of genetically diverse, and chronic liver diseases. This individual will be responsible for collaborating on novel drug candidates and helping build out a portfolio of programs with high potential for treatment of myriad of liver diseases.

Key Responsibilities:  

• Lead in the design and execution of in vivo and in vitro studies to generate key data for evaluating potential targets, mechanism of action and/or drug candidate efficacy and pharmacodynamics
• In collaboration with leadership, leads efforts to determine mechanism of action for drug targets and candidates using state-of-the-art methods and tools
• Build out a portfolio of programs with high potential for liver diseases into the early stage pipeline
• Identify KOLs and form collaborations and relationships to advance targets/indications of interest
• Act as a mentor to junior members of early-stage matrix project teams.
• Plan and execute in vitro and in vivo studies in collaboration with research scientists.
• Provide in vivo and ex vivo technical support for projects working to advance one or more experimental therapeutic compounds.
• Responsible for carefully documenting research and effectively communicating results across teams.
• Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas
• Manage a wide variety of tasks, techniques, and projects; integrate these responsibilities to produce quality results with a high level of efficiency

Required Qualifications:

• MS or PhD degree in a scientific discipline with 8+ years’ experience in drug discovery or target validation research with proven expertise in liver disease biology.

  Other Knowledge, Experience or Skills recommended:

• Expertise in the design and execution of in vivo and in vitro studies for the evaluation of liver-related biology (e.g. liver injury, NASH/fibrosis pathology) as demonstrated by a publication record in the field
• Deep knowledge of animal models of liver diseases including NASH and fibrosis and cell systems for evaluating interactions between hepatocyte, macrophage, stellate and/or endothelial cells
• Expertise in one therapeutic modality (gene therapy, gene editing, small molecules, antibodies & biologics, or ASOs/siRNA) and familiarity with the other modalities
• Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and, in a cross-functional team environment.
• Strong interpersonal skills, self-awareness, and ability to manage team dynamics
• Strong critical thinker who solves scientific problems using multiple technologies and approaches
• Adept at managing workload and expectations
• Proven success working in cross-functional teams with strong scientific and knowledge.
• Scientific driver for research strategy that impacts group internally and outside area of function
• Demonstrated ability to operate successfully in a fast-paced, dynamic and complex environment.
• Strong verbal and written communication skills.

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Company

Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

 Position Summary

We are seeking a passionate and creative, Associate Scientist to join our Cell Biology team and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company. This position reports to the Senior Scientist, Research.  The successful candidate will have a strong background in cell biology.

 Responsibilities:

• Responsible for the design, execution and analysis of a variety of in vitro cellular and molecular based assays, focused on understanding and optimizing our ADAR-mediated RNA editing platform
• Evaluate and troubleshoot new assays and techniques, as well as balancing a variety of tasks
• Participate in the development and scaling of novel cell based assays
• Deployment of cell-based models and assays for drug candidate screening and mechanism of action understanding
• Design, validate and implement high throughput NGS and qPCR-based assays
• Design and implement thoughtful and well controlled experiments
• Work various types of automated high throughput equipment

 

 

Education & Experience:

• MS (1-2 years’ experience) /BS (2-3) years’ experience in molecular and/or cellular biology, or a related field
• Broad experience in the application of biochemical, biophysical & cell-based techniques such as mammalian cell culture, transfections, various immunoassays such as Western Blotting, SDS PAGE and probe-based  qPCR
• Familiarity in the use of lab automation.  Must be able to analyze, report and communicate data rigorously
• The ability to learn and implement new techniques and adapt rapidly are essential.
• Excellent attention to detail, time management, and documentation
• Ability to multitask and successfully interact with a diverse team of scientists to deliver quality data and results
• Clearly present research updates to different project teams
• Motivated team player
• Strong interpersonal and communication skills (Oral/Written)
• Ability to balance multiple high-priority tasks in a rapidly changing environment

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.