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Company Summary:  Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary: Korro Bio is seeking a passionate and creative team leader with expertise in liver biology to join our Research group and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company.  Reporting to the Head of Liver Biology, the successful candidate will lead focused efforts on the validation of novel targets and the evaluation of novel drug candidates for the treatment of genetically diverse, and chronic liver diseases. This individual will be responsible for collaborating on novel drug candidates and helping build out a portfolio of programs with high potential for treatment of myriad of liver diseases.

Key Responsibilities:  

• Lead in the design and execution of in vivo and in vitro studies to generate key data for evaluating potential targets, mechanism of action and/or drug candidate efficacy and pharmacodynamics
• In collaboration with leadership, leads efforts to determine mechanism of action for drug targets and candidates using state-of-the-art methods and tools
• Build out a portfolio of programs with high potential for liver diseases into the early stage pipeline
• Identify KOLs and form collaborations and relationships to advance targets/indications of interest
• Act as a mentor to junior members of early-stage matrix project teams.
• Plan and execute in vitro and in vivo studies in collaboration with research scientists.
• Provide in vivo and ex vivo technical support for projects working to advance one or more experimental therapeutic compounds.
• Responsible for carefully documenting research and effectively communicating results across teams.
• Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas
• Manage a wide variety of tasks, techniques, and projects; integrate these responsibilities to produce quality results with a high level of efficiency

Required Qualifications:

• MS or PhD degree in a scientific discipline with 8+ years’ experience in drug discovery or target validation research with proven expertise in liver disease biology.

  Other Knowledge, Experience or Skills recommended:

• Expertise in the design and execution of in vivo and in vitro studies for the evaluation of liver-related biology (e.g. liver injury, NASH/fibrosis pathology) as demonstrated by a publication record in the field
• Deep knowledge of animal models of liver diseases including NASH and fibrosis and cell systems for evaluating interactions between hepatocyte, macrophage, stellate and/or endothelial cells
• Expertise in one therapeutic modality (gene therapy, gene editing, small molecules, antibodies & biologics, or ASOs/siRNA) and familiarity with the other modalities
• Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and, in a cross-functional team environment.
• Strong interpersonal skills, self-awareness, and ability to manage team dynamics
• Strong critical thinker who solves scientific problems using multiple technologies and approaches
• Adept at managing workload and expectations
• Proven success working in cross-functional teams with strong scientific and knowledge.
• Scientific driver for research strategy that impacts group internally and outside area of function
• Demonstrated ability to operate successfully in a fast-paced, dynamic and complex environment.
• Strong verbal and written communication skills.

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Company

Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

 Position Summary

We are seeking a passionate and creative, Associate Scientist to join our Cell Biology team and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company. This position reports to the Senior Scientist, Research.  The successful candidate will have a strong background in cell biology.

 Responsibilities:

• Responsible for the design, execution and analysis of a variety of in vitro cellular and molecular based assays, focused on understanding and optimizing our ADAR-mediated RNA editing platform
• Evaluate and troubleshoot new assays and techniques, as well as balancing a variety of tasks
• Participate in the development and scaling of novel cell based assays
• Deployment of cell-based models and assays for drug candidate screening and mechanism of action understanding
• Design, validate and implement high throughput NGS and qPCR-based assays
• Design and implement thoughtful and well controlled experiments
• Work various types of automated high throughput equipment

 

 

Education & Experience:

• MS (1-2 years’ experience) /BS (2-3) years’ experience in molecular and/or cellular biology, or a related field
• Broad experience in the application of biochemical, biophysical & cell-based techniques such as mammalian cell culture, transfections, various immunoassays such as Western Blotting, SDS PAGE and probe-based  qPCR
• Familiarity in the use of lab automation.  Must be able to analyze, report and communicate data rigorously
• The ability to learn and implement new techniques and adapt rapidly are essential.
• Excellent attention to detail, time management, and documentation
• Ability to multitask and successfully interact with a diverse team of scientists to deliver quality data and results
• Clearly present research updates to different project teams
• Motivated team player
• Strong interpersonal and communication skills (Oral/Written)
• Ability to balance multiple high-priority tasks in a rapidly changing environment

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Location: Remote (during COVID)

Company Summary:   Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary: We are seeking a dynamic Project Manager, to support our research efforts. The role requires a strategic leader who is experienced in drug development and understands the essential process, its complexity and its interdependencies.  A primary element, in the successful execution of this role will be establishing strong relationships across the program management roles that exists within line functions (Clinical Development, Pre-clinical Research etc.).  Through the leadership and facilitation of cross-functional program teams, this role is accountable for establishing a development plan, and an integrated cross-functional development strategy that includes timelines (including Gantt charts); dashboards and tools that provide transparency; budget inputs; identifying/highlighting risks and creating mitigation and/or contingency plans; and the attainment of key business goals/milestones.  This position will report to the Chief Legal Officer & Head of Corporate Strategy, and be based in our Cambridge, MA office.

Key Responsibilities:  

• Work proactively with the cross-functional program teams to define program strategy, goals, decision points, investments and areas of risk and associated mitigations and contingencies.
• Develop and maintain a fully integrated project plans (Gantt), incorporating activities, resource requirements, assumptions, responsibilities, and key interdependencies, key resource requirements and critical analysis that facilitate the delivery of quantifiable results against program and corporate goals.
• Lead data-driven decision-making processes to enable timely and objective recommendations for continuation, acceleration, reprioritization, redesign of the development plan.
• Communicate progress at all levels and escalate critical issues; provide regular status reports
• Identify, define, prioritize and communicate risks to successful activity and execution; develop and monitor risk mitigation and contingency plans.
• Track against R&D team budgets and contribute to long-range plan forecasts.
• Support the Leadership Team in setting goals and priorities developing agendas and planning workshops.
• Provide team and meeting management, including taking minutes and ensure follow-up of action items from the minutes. Prepare presentations as needed.
• Partner with R&D team to ensure effective coordination of activities and/or deliverables across functions, including assisting with the coordination and monitoring of external projects.
• Support implementation of systems and best practices to ensure consistency and operational effectiveness within and across functions and programs.
• Reinforcing or supporting team operating principles, team building, ensuring effective and high performing team.
• Supporting management of internal governance and decision-making processes.

Required Qualifications:

• B.S./M.S. degree in a life sciences discipline; advanced degree and/or MBA strongly preferred.
• A minimum of 7-10 years drug development experience in the biopharmaceutical industry including a minimum of 5 years project management or equivalent experience.
• Strong understanding of the drug development process in cell and/or gene therapy, including the strategic and operational requirements.
• Proven track record of success in leading and managing cross-functional development teams. Prior experience managing project to NDA submission a plus.
• Competency in developing, implementing, and delivering project plans (Gantt), dashboards and risk mitigation and contingency plans to successful endpoints.
• Self-directed, accomplishment-driven individual with a strong sense of passion and urgency who can work both independently and, in a cross-functional team environment.
• Demonstrated success with handling multiple projects and able to handle complexity and prioritize effectively.
• Proven success working in cross-functional teams with strong scientific and knowledge.
• Track record of collaboration, stakeholder relationship management, and influencing key decision makers.
• Knowledge of and skill with project management, spreadsheet and database management software/tools.
• Strong verbal and written communication skills.
• Ability to leverage broader perspectives and connect the major elements of drug discovery and development to proactively identify opportunities and provide options/solutions.
• Strong interpersonal skills, self-awareness, and ability to manage team dynamics.
• Must be motivated, creative, energetic and adaptable, responding constructively to challenging new ideas, information and situations.
• Demonstrated ability to operate successfully in a fast-paced, dynamic and complex environment.

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Company
Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary
Korro Bio is seeking an accomplished scientific leader who will play a key role in oligonucleotide delivery. The successful candidate will help identify delivery opportunities and optimize solutions across tissues and cell types. In this role, you will work closely with our internal groups such as: chemistry, screening, target biology, data science and development, as well as establish and maintain relationships with external collaborators and CROs.  The successful candidate will have a strong background in nucleic acid delivery, pharmacology, cellular trafficking as well as biochemical and cellular analysis.

Full-time, Onsite Only

Key Responsibilities

• Function as a key member of the research organization and be the person who knows everything about oligonucleotide delivery.
• Use your knowledge of oligo delivery to help guide a deeper understanding of and identify delivery solutions.
• Partner with other groups within research and development to help facilitate lead identification, optimization and development candidate nomination.
• Identify advisors and collaborators to help drive innovation in oligo delivery.
• Identify and execute on opportunities to improve and advance delivery.
• Serve as a role model and foster a scientifically rigorous, open and supportive scientific environment.
• Effectively communicate scientific planning, progress and results to constituencies within and outside of Korro.
• Communicate status updates and program issues to appropriate team members.

 

 

 

Required Qualifications

• Ph.D. in a relevant biological or chemical science.
• 10+ years of experience in solving complex problems in discovery or drug development, preferably in a biotech environment.

Other Knowledge, Experience or Skills Recommended

• Demonstrated accomplishment in the field of nucleic acids through publications and presentations and/or a track record in industry.
• Ideally have experience in all methods of oligonucleotide delivery including LNPs, oligo conjugates and other modes of delivery.
• Strong knowledge and hands-on experience with oligonucleotide delivery strategies.
• Experience with oligonucleotide pharmacology.
• Must be able to coordinate activities and integrate information across different functional groups including cell biology, pharmacology and chemistry.
• Demonstrates a proactive and collaborative philosophy and a hands-on approach to getting things done.
• Excellent written and communication skills to a variety of levels/teams- internally and externally.
• Must be able to identify and cultivate relationships with advisors and collaborators.
• Experienced in the delivery of oligo-based therapeutics to liver and other tissues with a proven track record of successfully solving drug delivery challenges would be ideal.
• Enthusiasm for being a hands-on manager with a passion for getting things done, no matter what it takes.

Benefits
Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

Company
Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary
Korro Bio is seeking a creative and rigorous scientist who will play a key role in continuing to drive our understanding of RNA editing through biochemistry and assay development. The successful candidate will work on characterization of ADAR/RNA and other biochemical processes and interactions and will develop, scale and implement new assays. This position will work closely with colleagues in chemistry, screening and target biology and other groups to expand our understanding of ADAR biology and biochemistry.

Position Type
Full-time, Onsite Only

Responsibilities

• Use your knowledge of biochemistry and protein nucleic acid interactions to help drive our RNA editing pipeline and platform
• Partner with other groups within research and development to help develop and implement assays to facilitate lead identification, optimization and development candidate nomination
• Identify collaborators to help drive innovation in RNA editing
• Effectively communicate scientific planning, progress and results to constituencies within and outside of Korro
• Execute deliverables adhering to timelines and budgets in a fast-paced environment