Join us

Location
Onsite, Lab Central

Company
Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary
Korro Bio is seeking a passionate and creative bioanalytical scientist to join our DMPK team and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company. The successful candidate is expected to perform bioanalysis, manage outsourcing and actively identify/develop new analytical technologies for oligonucleotide quantitation. Experience in the bioanalysis and familiarity with oligonucleotide bioanalysis would be a major advantage. It is highly desired that you will have extensive experience in applying high-resolution mass spectrometry to characterize metabolites and assess metabolic stability in various in vitro assay and in vivo animal models. The candidate will be motivated team player, have excellent interpersonal and communication skills and be able balance multiple high-priority tasks in a rapidly changing environment.

 

Key Responsibilities

• Develop high-quality LC-MS/ ELISA/PCR assays to quantitate oligonucleotides in biological matrices to understand the pharmacokinetics (PK) and ADME properties of drug candidates.
• Proven hands-on experience in various bioanalytical formats e.g. LC-MS/MS (Sciex/Thermo) is highly desirable.
• Responsible for sample analysis to support PK/PD and other non-clinical studies, interpret results and report data.
• Establish oligonucleotide stability profiling and metabolite identification.
• Work with CRO laboratories to transfer, qualify/validate bioanalytical assays, and support assay implementation.
• Present results at cross-functional team and lab meetings.
• Help maintain the bioanalytical lab and keep the instruments running properly.
• Proficient in using WinNonlin or other pharmacokinetic software

Required Qualifications

• Bachelor’s degree with 8+/ Master’s degree with 5+ years of post-graduate experience, or Ph.D. with a minimum of 2 years of relevant experience working in industry.
• Proven hands-on experience in various bioanalytical formats e.g. LC-MS/MS (Sciex/Thermo) is highly desirable.

 Benefits
Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

Job Title:
Head of Biology (Sr. Dir/VP)

Location:
Lab Central

Company Summary:
Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary:
Korro Bio is seeking a passionate and creative Head, Liver Biology to join our Development group and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company.  Reporting to the Head of Development, the successful candidate will lead a team focused on the validation of novel targets and the evaluation of novel drug candidates for the treatment of genetically diverse, chronic liver diseases. This individual will be responsible for bringing novel drug candidates and building out a portfolio of programs with high potential for treatment of myriad of liver diseases.

Key Responsibilities:  

• Lead efforts in the design and execution of in vivo and in vitro studies to generate key data for evaluating potential targets, mechanism of action and/or drug candidate efficacy and pharmacodynamics
• Bring novel drug candidates and building out a portfolio of programs with high potential for liver diseases into the early stage pipeline
• Act as senior scientific consultant to and/or leader of early-stage matrix project teams.
• Lead efforts to determine mechanism of action for drug targets and candidates using state-of-the-art methods and tools
• Prepare technical reports, summaries and quantitative analyses in written and/or oral form
• Proactively identify complex obstacles to progress in specific areas; recommend and implement solutions using a diverse set of resources; regularly add value to research projects through creative ideas
• Manage a wide variety of tasks, techniques, and projects; integrate these responsibilities to produce quality result with a high level of efficiency
• Support or identifies business development opportunities to enhance project progression, or functional capability expansion, with clear and specific application to needs of the liver portfolio

Required Qualifications:

• MD, MD/PhD or PhD degree in a scientific discipline with 12+ years’ experience in drug discovery or target validation research with proven expertise in liver disease biology.

Other Knowledge, Experience or Skills recommended: 

• Expertise in the design and execution of in vivo and in vitro studies for the evaluation of liver-related biology (e.g. liver injury, NASH/fibrosis pathology) as demonstrated by a publication record in the field
• Deep knowledge of animal models of liver diseases including NASH and fibrosis and cell systems for evaluating interactions between hepatocyte, macrophage, stellate and/or endothelial cells
• Expertise in one therapeutic modality (gene therapy, gene editing, small molecules, antibodies & biologics, or ASOs/siRNA) and familiarity with the other modalities
• Independently solves scientific problems using multiple technologies and approaches
• Independently manages workload and expectations
• Scientific driver for research strategy that impacts group internally and outside area of function
• Lead a high functioning group of scientists 

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Job Title:
Head, Translational Pharmacology

Location:
Lab Central

Company Summary:
Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary:
Korro Bio is seeking a passionate and creative Head, Translational Pharmacology to join our Development group and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company.  Reporting to the SVP, Development the Head, Translational Pharmacology will be responsible for the design, execution and interpretation of non-clinical pharmacology, toxicology, DMPK and translational studies in rodents, NHPs and other species (as needed). This work supports the progression of therapies from early discovery through first in human and proof of concept clinical studies.

Key Responsibilities:  

• Function as a key member of Korro Bio’s scientific leadership team, providing scientific expertise, strategic planning, and goal-oriented execution.
• Effectively communicate scientific planning, progress and results to Korro’s executive leadership, R&D teams, and external audiences. Additionally, build and develop appropriate relationships with key opinion leaders and SAB members.
• Represent Translational Pharmacology leader as a member of program, research, preclinical, and clinical teams.
• Serve as a role model and foster a scientifically rigorous, open and supportive corporate environment
• Propose pharmacology approaches and development of genetically engineered models (both mechanistic and/or disease models) at team discussions of high impact on project progression.
• Identify and manage consultants and vendors to support pharmacology-based studies.
• Contribute to candidate selection, development strategy, clinical trial design, clinical study protocols and execute and coordinate clinical trial conduct and finalize preclinical and clinical study reports.
• Partner with the discovery group to optimize preclinical models and inform first in human clinical dosing strategies.
• Review preclinical study reports, in conjunction with Pharmacokinetics/DMPK, safety, clinical, regulatory and rest of product development team prepare regulatory submission documentation.
• Author nonclinical pharmacology, in vitro and in vivo sections of regulatory documents.
• Collaborate cross functionally with all relevant areas to support strategic objectives
• Communicate status updates and program issues to appropriate team members.
• Participate in budgeting and due diligence activities.
• Execute deliverables adhering to timelines and budgets.

Required Qualifications:

• PhD, Pharm. D. or equivalent training in biology, pharmacology, pharmaceutical sciences or related disciplines.
• Minimum 15 years of experience in bio/pharmaceutical industry, combined with drug development experience in drug discovery and development with emphasis on pharmacology-based studies.

Other Knowledge, Experience or Skills recommended: 

• Strong knowledge and hands-on experience with oligonucleotide strategies and methodologies are preferred.
• Experience with regulatory submissions for small molecules with a focus on preclinical and early clinical development strategy and execution.
• Experience in nonclinical DMPK and toxicology is a plus.
• Expertise in one therapeutic modality (gene therapy, gene editing, small molecules, antibodies & biologics, or ASOs/siRNA) and familiarity with the other modalities
• Expertise managing CROs, GLP and other regulated activities.
• Ability to operate objectively and independently as a leader and as a member of a team.
• Excellent written and communication skills to a variety of levels/teams- internally and externally.
• Demonstrated persuasion, influencing and negotiation skills.
• Detail-oriented, with good organizational, prioritization, and time management proficiencies.
• Must be able to work on multiple projects simultaneously.

Benefits:

Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Job Title:
Head, Data Science

Location:
Remote (during COVID)

Company Summary:
Korro Bio is a privately held biotechnology company launched out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary:
Korro Bio is seeking a driven, smart and creative scientific leader whom will be responsible for building and leading Korro’s Data Science team. In addition to providing strategic and team leadership, key contributions for this position include the establishment and oversight of bioinformatic discovery using complex genomic data, including high throughput sequencing data from multiple platforms and databases.  Such work includes both internal and CRO based resources.  This scientific leader will have deep expertise in computational biology and in discovery research.  Core competencies include an ability to function in an interdisciplinary and quickly paced startup environment coupled with a proactive and collaborative approach. This position will report to the SVP of Technology.

Key Responsibilities:  

• Function as a key member of Korro Bio’s scientific leadership team, providing scientific expertise, strategic planning, and goal-oriented execution.
• Build, lead and mentor a small team of Bioinformatics & Data Scientists.
• Partner with other groups (e.g. informatics, platform biology, pharmacology) within research and development to facilitate lead identification, optimization and development candidate nomination.
• Identify appropriate CROs and manage contract research to ensure success in meeting Korro’s chemistry goals and milestones.
• Build strong relationships enabling trust, respect and effective collaboration cross disciplinary colleagues to ensure productive and successful company-wide research and development programs.
• Serve as a role model and foster a scientifically rigorous, open and supportive corporate environment
• Effectively communicate scientific planning, progress and results to Korro’s executive leadership, R&D teams, and external audiences. Additionally, build and develop appropriate relationships with key opinion leaders and SAB members.

Required Qualifications:

• Ph.D. in quantitative discipline or comparable experience: Bioinformatics, Statistics, Applied Mathematics, Computer Science, Biophysics, Computational Biology, Physics, Engineering or Machine Learning. M.S. degree with extensive (at least 10 years) Industry experience will also be considered.
• Minimum of 10 years of Industry experience with proven leadership and management skills, ability to build and mentor high- performing teams.
• Experience analyzing gene therapy, gene editing, in vitro/vivo assay, genetics, genomics and cell biology data
• Experience analyzing the multiple facets of next generation sequencing data, including amplicon sequencing, tag counting, exon sequencing
• Experience using comparative genomics as a tool for gene discovery
• Passionate scientist and leader with high emotional intelligence and communication skills adept at working in a rapidly growing and dynamic biotech environment whom is able to progress programs under aggressive timelines.
• Pragmatic, solution-oriented thinker who possesses a “can do” and “whatever it takes” attitude, coupled with excellent organizational skills.
• Hands-on approach with meticulous attention to detail.
• Strong interpersonal skills with the ability to motivate and influence others, negotiate during situational conflict and establish the best forward path in the face of competing points of view.
• Track record of collaboration, stakeholder relationship management, and influencing key decision makers.

Benefits
Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

Company
Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary
Korro Bio is seeking a passionate and creative scientist to join our oligonucleotide discovery chemistry team and work with an enthusiastic team of highly skilled scientists in a dynamic, high growth company. The successful candidate will have a strong background in oligonucleotide chemistry and bioconjugation chemistry and independently assist in all aspects of design, synthesis, bioconjugation, purification and chemical/biophysical characterization of novel oligonucleotides to advance our RNA editing drug discovery programs.

Position Type
Full-time, Onsite Only

Responsibilities

• Design and execute the automated high throughput solid-phase synthesis, purification and analysis of novel oligonucleotides with various chemical modifications and scales using modern synthesis platforms
• Design and execute various bioconjugation strategies and techniques to prepare novel oligonucleotide conjugates
• Method/process development for improved oligonucleotide synthesis and purification processes
• Operate, maintain & troubleshoot oligonucleotide synthesis platforms, HPLCs and other scientific equipment
• Prepare samples and perform thermal melting (Tm) experiments and analyze the data
• Track progress, analyze, organize, and present data at internal and external meetings
• Write standard operating procedures, maintain a well-documented electronic/laboratory notebook and internal oligonucleotide inventory.

Qualifications

• Ph.D in nucleic acids chemistry/organic chemistry/medicinal chemistry with 2 – 5 years’ experience in the biotechnology or pharmaceutical industry or academic equivalent
• Basic computer skills including MS Office Suite
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Company
Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary
Korro Bio is seeking an accomplished scientific leader who will play a key role in oligonucleotide delivery. The successful candidate will help identify delivery opportunities and optimize solutions across tissues and cell types. In this role, you will work closely with our internal groups such as: chemistry, screening, target biology, data science and development, as well as establish and maintain relationships with external collaborators and CROs.  The successful candidate will have a strong background in nucleic acid delivery, pharmacology, cellular trafficking as well as biochemical and cellular analysis.

Full-time, Onsite Only

Key Responsibilities

• Function as a key member of the research organization and be the person who knows everything about oligonucleotide delivery.
• Use your knowledge of oligo delivery to help guide a deeper understanding of and identify delivery solutions.
• Partner with other groups within research and development to help facilitate lead identification, optimization and development candidate nomination.
• Identify advisors and collaborators to help drive innovation in oligo delivery.
• Identify and execute on opportunities to improve and advance delivery.
• Serve as a role model and foster a scientifically rigorous, open and supportive scientific environment.
• Effectively communicate scientific planning, progress and results to constituencies within and outside of Korro.
• Communicate status updates and program issues to appropriate team members.

 

 

 

Required Qualifications

• Ph.D. in a relevant biological or chemical science.
• 10+ years of experience in solving complex problems in discovery or drug development, preferably in a biotech environment.

Other Knowledge, Experience or Skills Recommended

• Demonstrated accomplishment in the field of nucleic acids through publications and presentations and/or a track record in industry.
• Ideally have experience in all methods of oligonucleotide delivery including LNPs, oligo conjugates and other modes of delivery.
• Strong knowledge and hands-on experience with oligonucleotide delivery strategies.
• Experience with oligonucleotide pharmacology.
• Must be able to coordinate activities and integrate information across different functional groups including cell biology, pharmacology and chemistry.
• Demonstrates a proactive and collaborative philosophy and a hands-on approach to getting things done.
• Excellent written and communication skills to a variety of levels/teams- internally and externally.
• Must be able to identify and cultivate relationships with advisors and collaborators.
• Experienced in the delivery of oligo-based therapeutics to liver and other tissues with a proven track record of successfully solving drug delivery challenges would be ideal.
• Enthusiasm for being a hands-on manager with a passion for getting things done, no matter what it takes.

Benefits
Korro offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.

 

Company
Korro Bio is a privately held biotechnology company launching out of a top-tier life science venture firm headquartered in Cambridge, Massachusetts. We are utilizing the precision provided by nucleic acid-based therapeutics to target the sequences responsible for inherited disorders within the genetic code. At Korro Bio, our aim is to bring transformative treatments to patients with rare and debilitating diseases by addressing the underlying genetic cause.

We are committed to investing in the personal and professional growth of our employees by putting work-life balance, family values and expanding an employee’s knowledge at the forefront. This has helped to shape us into an energetic, inclusive and innovative team where your value is celebrated no matter your role.  Together we intertwine our positive culture and intrinsic motivation with our passion for advancing science to directly impact the future of RNA editing one letter at a time.

Position Summary
Korro Bio is seeking a creative and rigorous scientist who will play a key role in continuing to drive our understanding of RNA editing through biochemistry and assay development. The successful candidate will work on characterization of ADAR/RNA and other biochemical processes and interactions and will develop, scale and implement new assays. This position will work closely with colleagues in chemistry, screening and target biology and other groups to expand our understanding of ADAR biology and biochemistry.

Position Type
Full-time, Onsite Only

Responsibilities

• Use your knowledge of biochemistry and protein nucleic acid interactions to help drive our RNA editing pipeline and platform
• Partner with other groups within research and development to help develop and implement assays to facilitate lead identification, optimization and development candidate nomination
• Identify collaborators to help drive innovation in RNA editing
• Effectively communicate scientific planning, progress and results to constituencies within and outside of Korro
• Execute deliverables adhering to timelines and budgets in a fast-paced environment